Best Fat Burners: Top Fat Burning Pills and Thermogenic Supplements (2022 Update)

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Natural fat burners have helped many in their weight loss journeys. Understanding how these diet pills work will make it easy to choose the supplement most suitable to your unique needs. Fat burners also come with very potent ingredient concentrations that may react with some medications, so the more you know, the safer you’ll be.

This article covers the six best fat burners available, their ingredients, side effects, and the safest ways to take each product.

Best Fat Burners

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Quick Verdict

PhenQ is the best fat burner we found. Its ingredients are linked to very powerful thermogenic fat breakdown effects. Instant Knockout is a close runner-up and its strong thermogenic properties make it good for men struggling with stubborn fat. Lean Bean, on the other hand, is designed to work with the female body and streamline a woman’s weight loss journey.

If you’re looking to lose weight, burn stored fat, or handle your food cravings using natural ingredients, here are some of the best fat burner supplements reviewed in detail below.

1. PhenQ – Best Fat Burner Overall




PhenQ is another one of the best fat burners offering thermogenic weight reduction effects. Its range of ingredients in the α-Lacy’s reset formula aims to boost your energy levels while helping you lower your body fat percentage.

The weight loss supplement owes its effectiveness to its blend of ingredients that include:

  • Capsimax: A blend of capsicum, cayenne pepper, black pepper, caffeine, and vitamin B3 offers powerful thermogenic effects.

  • Caffeine.

  • Nopal: Nopal cactus is a plant that’s high in fiber and amino acids, providing you with energy while keeping you fuller for longer. It may also help reduce your body’s fluid retention and enhance your overall weight loss rate [10].

  • L-carnitine fumarate: This amino acid is important for digestion, promoting the healthy processing of food and encouraging your body to burn extra fat, leading to weight reduction [11].

  • Chromium picolinate: This natural mineral is said to lower your sugar cravings.

Bottom Line

PhenQ is a premium quality thermogenic fat burner that promotes long-term weight loss with the addition of high-fiber ingredients for enhanced satiation, and thermogenic components to help you lose weight faster.

>> Check the best price for PhenQ

2. Instant Knockout – Best Supplement for Intensive Exercise

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Instant Knockout is one of the best fat burners to use alongside resistance training. Its ingredients boost your energy levels, burn fat, and encourage your body to lose weight, and are well researched and backed up by clinical trials.

Ingredients and benefits offered by Instant Knockout include:

  • Green tea extract: Green tea plays a significant role in fat breakdown when taken as a supplement. It is most effective in preventing fat accumulation, and boosting the breakdown of fat or lipolysis [6].

  • Vitamin D3: Alongside a low-calorie, balanced diet, taking vitamin D3 can help you lose extra weight and burn extra fat [7].

  • Cayenne pepper.

  • Black pepper extract.

  • Caffeine anhydrous: Caffeine may not just help boost your energy or motivate you to lose the last few pounds. It could contribute to successful weight loss maintenance, too [8].

  • Vitamin B6: Certain B vitamins like B6 can help prevent weight gain while maintaining weight and fat loss [9].

  • Vitamin B12: Vitamin B12 may help your body fight against obesity while helping you burn fat and become and stay lean.

Bottom Line

Instant Knockout provides a range of excellent benefits for burning fat and shaping your body. However, the only major drawback is the 90-day money-back guarantee that only covers unused, unopened bottles.

>> Check the best price for Instant Knockout

Caution: Instant Knockout may not be suitable for anyone with caffeine sensitivity. This supplement contains 500 mg of green tea extract, 100mg of green coffee extract, and 350 mg of Caffeine Anhydrous per serving. The recommended dose of caffeine per day for a healthy adult is 400mg. Alternatives like PhenQ and LeanBean may be a better fit as they contain little or no caffeine.

3. Lean Bean – Best Fat Burner for Women

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LeanBean fat-burning supplement is one of the best fat burners for women on the market. The fat burner consists of ingredients that boost energy levels and healthy fat breakdown to promote lasting weight loss.

Ingredients in LeanBean include:

  • Glucomannan: Serves as a natural appetite suppressant to promote healthy, long-term weight loss [17].

  • Choline: As an essential nutrient produced by your liver, choline can help boost fat breakdown and other bodily functions, encouraging weight loss [18].

  • Vitamin B6.

  • Vitamin B12.

  • Chromium picolinate.

Bottom Line

LeanBean is a weight loss supplement designed specifically for women to tone and contour their arms, tummy, and legs using an all-natural formula beneficial to their overall health.

>> Check the best price for LeanBean

4. Burn Lab Pro – Best Fat Burner for Men

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  • Clinically-researched ingredients.

  • Stimulant and caffeine-free.

  • Free international shipping.

  • Contains an optimal dose of each ingredient.


Burn Lab Pro is a fat-burning supplement that not only helps you lose those extra pounds but could also help you burn fat around your waist.

The natural ingredients in Burn Lab Pro offer a range of fat-burning properties, including:

  • Forslean: A form of the Ayurvedic plant Coleus forskohlii, Forslean provides significant fat reduction benefits while promoting muscle gain [1].

  • Capsimax: As a cayenne pepper fat burner, Capsimax regulates fat-burning hormones and could help reduce your caloric intake while boosting your energy levels [2].

  • HMB ß-hydroxy ß-methyl butyrate: HMB is a natural ingredient that can help promote weight reduction while preserving your muscle gains and mass [3].

  • Nutragenesis GTF Chromium: Chromium is a mineral that can enhance fat loss and an equally distributed body composition by improving the activity of insulin in your body [4].

  • Black pepper extract: Piperine, or black pepper extract, may help burn extra fat through its thermogenic effects [5].

When accompanied by exercise and a healthy, low-calorie diet, Burn Lab Pro should help you post quick positive results.

Bottom Line

Burn Lab Pro is a thermogenic, natural fat burner that helps you lose weight, build muscle, and boost your energy levels with minimal side effects.

>> Check the best price for Burn Lab Pro

5. PhenGold – Best Fat Burner for Energy




PhenGold’s ingredients aim to burn fat, targeting the stubborn fat that can’t typically be burned by normal exercise. Its formula can also help maintain your muscle mass while elevating your energy levels to do even better in the gym.

Ingredients in PhenGold include:

  • Green tea extract.

  • L-theanine: L-theanine is an amino acid present in green tea extract that not only helps you lose weight but could boost your cognitive function and overall mood [12].

  • Rhodiola SP: Rhodiola extract has been proven useful for weight reduction as well as burning fat [13].

  • Green coffee bean extract: The extract may be significantly effective at reducing body fat and aiding overall weight reduction [14].

  • L-tyrosine: Accompanied by a low-calorie diet, L-tyrosine can cause significant weight loss while boosting brain function and mood [15].

  • Cayenne pepper: The capsaicin in cayenne pepper can suppress your appetite and help you stick to a low-calorie diet necessary for weight and fat reduction [16].

Bottom Line

PhenGold offers a range of thermogenic ingredients that can help suppress cravings, boost your fat breakdown, and positively affect your mood and mental health.

>> Check the best price for PhenGold

6. Zotrim – Top Fat Burner to Suppress Hunger




  • Moderate side effects.

  • Only available online.

Zotrim is a fat-burning supplement with a number of unique ingredients not found in other weight loss supplement options.

Its ingredients work to burn extra fat and get rid of stubborn fat areas while boosting your energy levels and include:

  • Yerba mate leaf extract: This may help reduce your caloric intake while promoting overall weight loss [19].

  • Guarana seed extract: Guarana contains more caffeine than coffee and may promote weight loss while boosting energy levels due to its stimulant effect [20].

  • Caffeine.

  • Vitamin B3.

  • Vitamin B6.

Bottom Line

Zotrim is a fat burner that contains unique ingredients like yerba mate and guarana aimed at helping you lose extra weight and tone your body. It has high concentrations of caffeine, which may cause some adverse effects like jitters and headaches.

>> Check the best price for Zotrim

What Makes a Fat Burner Unique for Men?

If you’re looking for a natural fat burner supplement as a male, there are a few things you should consider. You may want the ingredients to increase muscle growth or boost energy levels at the same time. Most men require powerful thermogenic supplements to boost their fat loss, and finding the right option for you may require trying a few different types first.

What Do Fat Burners Really Do?

The best fat burner supplements work by activating and enhancing your metabolism and fat-burning process while also suppressing appetite and boosting overall energy levels.

By boosting your ability to burn body fat alongside a good diet and exercise, a natural fat burner helps you lose weight with minimal side effects.

When Should I Take Fat Burners?

Fat-burning supplements should be taken once you reach a plateau in your exercise and weight-loss regimens. To get the most out of the fat-burning process, you should use your fat burner before or with breakfast as soon as you wake up.

This could also help supplements with large doses of caffeine not keep you from sleeping at night. However, these times don’t need to be adhered to so strictly for a stimulant-free fat burner.

Benefits of Fat Burners

Male fat burners offer a few benefits not always included in standard, unisex fat burner options, including:

  • Promoting fat breakdown while maintaining muscle mass.

  • Raising your energy levels with the use of stimulants to give you a boost during weight training or resistance workouts.

  • Focusing heavily on boosting your exercise abilities to help you burn excess fat.

  • Some male fat burners may even contain testosterone boosting ingredients to elevate your sex drive while building muscle and losing fat naturally.

Fat-burning pills can also positively influence men’s lifestyles. Obesity can lead to low testosterone, resulting in decreased sex drive, loss of muscle, and fatigue [21].

Potential Side Effects of Fat Burner Supplements

Although natural fat burners usually have far fewer side effects than synthetic ones, you may still experience a few adverse effects after taking your daily dose.

Common general side effects may include:

  • Nausea.

  • Bloating.

  • Constipation.

  • Stomach ache.

  • Headaches.

Another standard set of side effects are related to the presence of stimulants like coffee bean extract, green tea extract, or guarana, all of which contain caffeine.

High doses of caffeine could cause:

  • Jitters.

  • Restlessness.

  • Headaches.

  • Dizziness.

  • Elevated heartbeat.

  • Anxiety.

However, if dosage instructions are adhered to, these side effects are rare and often very mild.

Things To Look for in the Best Fat Burners

When looking for the top fat burner supplements for men, you should take a few things into consideration.


Ingredients are the most important factor to consider when choosing a natural fat burner.

Some points to look out for are:

  • Choose fat-burning ingredients that have been clinically studied and researched to prove the benefit or initiate the fat-burning process in your body.

  • Look for supplements that contain thermogenic fat burners like caffeine, green tea, or black pepper.

  • Avoid stimulants unless you are certain you want the added energy and are okay with the possible side effects.

Don’t use supplements that claim to be the only thing you need to start natural weight loss. All reputable fat burn supplement brands will be clear that a healthy diet and exercise are necessary to lose weight even when using their product.

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The group drinking four cups of green a day for eight weeks saw the biggest difference in weight


Not all fat-burning supplements are equally effective. Reading customer reviews on their experience with the product can help you gauge what the supplement does, whether it helps to burn belly fat, promotes overall fat reduction, boosts your body’s metabolism, or just gives you the boost of your energy levels to workout. Understanding how the supplement works is essential, so you know what results to expect.


Each fat burner supplement will have a different dose optimized to help your body burn extra fat. Consider whether this dose is easy to take and remember, like two capsules a day, or if it requires taking several doses over the course of the day that may be more difficult to stick to.

Also, check the amount of each ingredient on the label. Make sure each fat-burning ingredient is present in high enough amounts per serving to be beneficial.


Most fat-burning pills aim to do exactly as their name states, help you lose fat. However, each fat burner may also have a unique set of additional benefits to help you decide on the right one.

Some of these extra benefits include:

  • Targeting stored fat.

  • Preventing fat accumulation.

  • Boosting your mood.

  • Increasing your energy.

  • Promoting the build-up of muscle.

  • Suppressing your appetite.

Side Effects

Although most natural fat burners will help you start losing weight without significant side effects, there is still a risk of experiencing things like headaches, stomach pain, dizziness, and constipation.

Before choosing a supplement, familiarize yourself with its possible side effects and, if the adverse effects of these options bother you, you may need to opt for one of the many stimulant-free fat burners available.

What’s the Top Fat Burner Supplement?

Fat-burning supplements each come with their own set of benefits and abilities to help you burn fat. However, the best excess fat burners are often thermogenic fat burners, as their ingredients not only promote weight loss but could boost your metabolism.

The two overall best supplements are discussed below.

Best Thermogenic Fat Burner

There are many thermogenic fat burner supplements out there, but the best we found was PhenQ. With ingredients like caffeine, capsicum. black pepper, and chromium, in moderate concentration, you potentially get a very strong thermogenic response with minimal side effects.

Top Fat Burner for Women

LeanBean is the best fat burner for women as it boosts your body’s metabolism to promote fat reduction through 100% natural ingredients like:

  • Caffeine.

  • Green coffee bean extract.

  • Green tea.

  • Glucomannan.

  • Grains of paradise, which is a herb related to the ginger family, and could help extract and break down stored fat [22].

Women often require a fat burner supplement that targets stored fat and contains more beneficial vitamins and natural energy boosters.

Best Fat Burner Supplements – FAQ

Below are some of the most frequently asked questions about fat burner supplements.

Are Fat Burners Good for Weight Loss?

Natural fat burners and fat burner supplements can help promote total body and belly fat loss. However, this is only possible when used as part of a low-calorie, healthy diet accompanied by regular exercise.

The fat-burning ingredients in these supplements are regularly research-backed, but they are not miracle drugs and won’t help you lose extra weight without any lifestyle changes.

What Are the Side Effects of Fat Burners?

Even the best fat-burning supplements can cause a few mild side effects.

The most common side effects experienced when using most fat burners include:

Is Hydroxycut a Fat Burner?

Hydroxycut is a family of supplements, many of which can help you lose weight using similar ingredients to each of the fat burner supplement brands listed above.

Do Fat Burners Cause Baldness?

Although fat-burning pills don’t explicitly cause hair loss, the appetite suppression and low-calorie diets that accompany them while trying to lose weight could cause a lack of the proper nutrition to promote hair health.

If you’re taking a weight loss pill, you should also take a multivitamin to ensure your body receives all the nutrients it needs to function at its best.

So What are the Best Fat Burners in 2022?

Natural fat burners are a great way to boost your body’s ability to get rid of excess fats and improve your health. Our top recommendation would be PhenQ, and Instant Knockout for potency, and LeanBean for women.

That said, these supplements are not miracle drugs. They should only form part of a healthy weight loss journey that relies heavily on a good diet and exercise regimen to ensure you get the most benefit from your efforts.


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Shannon Ancrum is a freelance writer specializing in health content. She’s gifted at unraveling complex medical jargon and explaining it to her readers simply and clearly.

Daniel Boyer is a practicing Doctor of medicine with a passion for medical research. He specializes in molecular biology, histology, and pharmacology.

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