Best Nootropics Supplements & Smart Drugs of 2022

Do you ever have moments when your brain goes foggy? Or how about those moments when you just draw a blank? These symptoms are usually followed by you feeling unproductive or possibly mentally drained. 

As we leave our youth and grow into adulthood, it is vital for us to stay focused to ensure we perform at our best capabilities. If you are tired of feeling this way, then maybe you should dive into the world of nootropics. But, what is a nootropic, you ask? Let us get into that first. 

Nootropics are a type of supplement that may have the ability to help enhance your cognitive functions, creativity, memory, and much more. Adding these supplements to your daily routine may play a role in improving your overall performance. 

In addition, they may be able to help you take on your daily tasks and responsibilities. These supplements are known to have a beneficial effect on the overall functions of your brain.

They may also be able to help aid in any mental declines that may happen with age. So, if you have been feeling unmotivated lately and unsure of how to stimulate yourself, nootropics may just be the answer for you. 

Top 3 Best Nootropics Supplements

  1. NooCubeOverall Best Smart Drug Infused with Bacopa Monnieri
  2. Mind Lab Pro – Premium Smart Drugs for Boosting Brain
  3. Qualia Mind – The Most Advanced Formulas


#1. NooCube – Overall Best Smart Drug Infused with Bacopa Monnieri

Starting off our Top three list is NooCube, which was designed by top neuroscientists. These neuroscientists had a goal to create a smart drug that would effectively improve your cognitive functioning. They took into great consideration which ingredients to use in their formulation for this supplement.

Each ingredient included in their formula was rigorously tested to ensure safety when using their product, and their ingredients are supported by decades of clinical research. The most interesting thing about NooCube is that they have been considered as potential treatments for patients that suffer from brain diseases like Alzheimer’s and Dementia. 

NooCube is caffeine-free as well. Although caffeine is a known nootropic, it does little to get you into an active state of mind. They want you to reap the benefits of nootropics without the jitters. Overall,their goal is to help you push the limits and reach the best version of yourself. 


  • May enhance multitasking skills 
  • May improve concentration
  • Free worldwide shipping
  • 60-day money-back guarantee
  • Multitude of scientific evidence on the efficacy of the ingredients used
  • No known side effects 
  • Only two capsules needed
  • Works in as little as 30 minutes
  • An informative guide on nootropics is listed on their website 


  • Shipping charges not included in refunds


High-Quality Ingredients

NooCube is made up of 7 powerful ingredients, which were designed to improve your cognitive functions quickly and safely. Let us go over what NooCube’s formula is made up of.

Alpha Glycerylphosphorylcholine: (Alpha GPC) Is an ingredient that is thought to increase the levels of acetylcholine in the brain. Acetylcholine is a neurotransmitter that is considered a chemical messenger, which communicates between brain cells. This is vital when it comes to memory, learning, and concentration. A study was conducted in 2013 where Alzheimer’s patients were given Alpha GPC three times a day for 180 days. These patients demonstrated consistent improvements in their cognitive function test scores compared to those patients that were taking only a placebo. People with dementia were also given Alpha GPC for 90 days and showed symptomatic improvement after taking psychometric tests.

Huperzine A: Huperzine A is an acetylcholinesterase (AChE) inhibitor, which prevents acetylcholine levels from decreasing.  This ingredient also creates a large amount of acetylcholine, leading to improved mental clarity, concentration, and memory. In 1999, a study was conducted where young adults were given this ingredient for four weeks. Within those four weeks, the adolescents that were given huperzine had an improved learning and memory performance compared to those who were just taking a placebo. There is also another study where Alzheimer’s patients were treated using huperzine, and 58% of the patients showed improvement in memory

Cat’s Claw: Cat’s Claw is derived from a vine that grows in the Amazon Forest, and it is believed to have neuroprotective benefits. It is filled with antioxidants that could help improve your brain’s health and cognitive performance. One study investigating this antioxidant shows that it was able to destroy different types of free radicals and protect against overall cell damage. The researchers behind this study determined that Cat’s Claw could possibly be used to prevent Parkinson’s Disease.

Bacopa: Bacopa is an Indian herb that is thought to help repair damaged neurons and promote new nerve growth. Bacopa is yet another one of NooCube’s ingredients in their formula that has the potential to help Dementia and Alzheimer’s patients. In addition, Bacopa could possibly help with any cognitive declines that come with age. In 2005, an Australian study showed people taking 300mg of bacopa extract daily for 12 weeks. After this test was over, the people that took bacopa extract showed a significant improvement in their memory compared to those who were only taking a placebo.  Another study conducted in 2008 showed cognitive improvement in elderly participants within a 12-week period after taking bacopa. 

Oat Straw: Oat Straw comes from wild green oats and has been used as a brain booster since the Middle Ages. It is believed to work by increasing A2 waves in the brain and controlling inflammation within artery walls. By doing this, it will help increase blood flow to the brain, helping you feel more awake and alert.  A study in 2015 gave volunteers 800mg of green oat extract each day for six days. Afterward, they assessed their cognitive function using computerized tasks. Those who took green oat extract completed tasks faster and performed better in memory tasks.

L-Theanine And L-Tyrosine: L-Theanine is found in green and black tea. It is an amino acid that can help relieve stress while stimulating neurotransmitters in the brain. This can help create a relaxed yet alert feeling. L-Tyrosine Is another amino acid that is involved in the manufacturing of dopamine and noradrenaline. These neurotransmitters play a vital role in mental alertness and focus. L-Tyrosine may help improve cognitive performance by reducing stress and fatigue. A study in 2011 showed that both attention and memory in the volunteers significantly improved after taking L-Theanine and green tea extract for 16 weeks. Another study shows that L-Tyrosine improved cognitive flexibility, meaning it helped with the brain’s ability to switch between thinking about one topic to another.

All of these ingredients were put through extensive studies to prove the efficiency and benefits that each one has. These ingredients are high quality and proven to help aid in cognitive function.

Side Effects

Safety was NooCube’s priority when creating its formula. As a result, none of the ingredients listed in their formula have been shown to cause any negative side effects. 

Each ingredient has undergone rigorous safety checks, and NooCube has not used any ingredient that is not supported by research and studies. A clinical studies section is also listed on their page for your assurance.


Each bottle of this supplement contains 60 capsules, and the recommended serving size is 2 capsules a day, meaning each bottle will contain 30 servings. These capsules should be taken with breakfast every morning. 

The results may vary between each person, so it is recommended you start by taking two capsules a day before experimenting with your dosage. 

This could possibly mean that as your body adjusts to the dosage, you may be able to increase the capsules taken to three to four a day. However, do not exceed four capsules per day.

Money-Back Guarantee

NooCube is positive that you will be happy with your purchase, but if something arises where the results are not what you desired, you will be able to receive 100% of your money back, including shipping and handling. 

All you have to do is contact their customer support team through their email address [email protected]

⇒ Visit the Official Website of NooCube

#2. Mind Lab Pro – Premium Smart Drugs for Boosting Brain

Mind Lab Pro is another brand that carries a nootropic, and they believe in uncapping your true potential. Mind Lab Pro understands that the human brain is the most complex object in the known universe, and it is capable of amazing things but sometimes needs a little boost. If we were to compare the human brain to a hard drive, it is capable of storing up to 2.5 million gigabytes of information. 

That is a whole lot of information. Some nootropic supplements may only target two to three brain pathways. Plus, some of them only use botanicals or synthetics. But, Mind Lab Pro wants to help support every part of the brain. 

They aim to unlock 100% of your brainpower by optimizing as many brain functions and pathways as possible. Their goal is to help you meet mental performance demands that can change from day to day. 

They also avoid all stimulants and additives to provide a clean and safe formula that everybody can take. Mind Lab Pro may help with immediate performance needs and long-term brain health functions. 

Their supplement optimizes six different brain pathways through brain chemistry, brain energy, brain regeneration, brain circulation, brain protection, and brain waves. 


  • All-natural with no synthetic materials are used
  • No known side effects
  • Designed to help improve brain functions, health, and stress resistance
  • Designed to help in all age groups
  • Extensive third-party testing has been done 
  • Can be bought from anywhere in the world 
  • 60-day money-back guarantee
  • Dosage amount of two to four capsules a day 
  • Vegan-friendly and non-GMO
  • Recyclable packaging is used


  • Only available for purchase through their website
  • To receive a full refund, you must wait 60 days, and you will not be refunded for the shipping costs


High-Quality Ingredients

Mind Lab Pro wants you to feel comfortable using their product by showing you exactly what is inside their formula. They aim to show you all of the ingredient dosages and details on every label. They strongly believe you have the right to know what you are putting in your body and brain. 

Cognizin: (250 mg Citicoline) This ingredient is known to provide boosts of energy to the brain, and it is also a potent nutrient that may be beneficial to the brain. Cognizin can support mental clarity and focus and can give you energy boosts without the worry of experiencing a crash later. This often happens with heavily caffeinated products. Cognizin may also have the ability to improve your overall mood.

Phosphatidylserine (PS): (100 mg) PS is one of the chemicals found within the brain and has been used to treat the severe disease Alzheimer’s. It helps with mental improvement for Alzheimer’s patients, and it has even been used to help treat people diagnosed with ADHD. It also makes up a small portion of the fatty parts of the brain (approximately 15%).

Bacopa Monnieri: (150 mg) Bacopa Monnieri is an herb that has been used in ancient medicine for years. It has been used widely to help with memory recognition, and it has also been known to help with anxiety. 

Organic Lion’s Mane Mushroom: (500 mg) Lion’s mane mushroom has been known to have several medicinal properties, such as protecting the brain from diseases like dementia. Lion’s mane mushroom may also help with nerve growth. 

Maritime Pine Bark Extract: (75 mg) The bark from the Maritime Pine Tree has been used for years to create medication. This ingredient may have anti-inflammatory properties that may improve diseases like Alzheimer’s.

L-Tyrosine: (175 mg) This ingredient has been known to help people with multitasking, as it can help people improve their overall mental performance day by day. L-Tyrosine is an amino acid that is an important factor in the production of dopamine along with other brain chemicals. L-Tyrosine has been able to help people achieve better sleep and improve their mental alertness.

L-Theanine: (100 mg) L-Theanine may be able to help decrease the chemicals that produce stress and anxious feelings, which can help put your mind and body at a more relaxed state.

Rhodiola Rosea: (50 mg) Rhodiola Rosea has been used for thousands of years for its properties to improve cognitive functions. This ingredient can help improve your learning capabilities. Rhodiola Rosea is a common nootropic ingredient known to help with brain health improvement, and it has been used to help mental improvement for Alzheimer’s patients.

B6 (2.5 mg) B9 (100 mcg) B12 (7.5 mcg): B Vitamins play a vital role in the overall health of the brain. These vitamins combined may be able to help in the prevention of dementia, and they also help in the creation of neurotransmitters, which are responsible for sending messages between the brain and body. Vitamin B12 may be able to help with the symptoms followed by Alzheimer’s.

Side Effects

All ingredients in the Mind Lab Pro supplement are completely safe for use. Mind Lab Pro is the only nootropic supplement of its kind to carry a clean label. Even the capsules used to hold the formula are 100% clean and safe for vegans to use. There are no known side effects connected to the Mind Lab Pro nootropic supplements.


Two capsules should be taken in the morning or early afternoon. If you know you are going to experience a day where high cognitive functions are a demand, the dosage may be increased to four capsules in total. Do not take more than four capsules within a 24-hour period.

Money-Back Guarantee

Your first order with Mind Lab Pro is covered with a 30-day money-back guarantee. So, you are able to try their products risk-free with no worries. If you do not like their supplement, you can easily ask for a refund and you will not be stuck with a useless product. 

After your first purchase with Mind Lab Pro, any other returns must be processed within 14 days of receiving your product.

⇒ Visit the Official Website of Mind Lab Pro

#3. Qualia Mind – The Most Advanced Formulas

NeuroHacker was founded back in 2015 with a goal in mind — to create high-quality nootropic supplements that can perform at the top of its class. They used extensive research based on the complex system of science in order to create their nootropic supplement Qualia Mind. 

Their approach focused on supporting the body’s ability to self-regulate rather than using chemicals that would only move the internal biomarker in a particular direction.  

They have a long list of scientific and medical advisors that helped them create Qualia Mind. The crazy thing about this brand is that it offers a wide range of different types of nootropic supplements targeting certain areas. 

Some of their supplements help aid in vision, immunity, better sleep, mental performance, aging, and much more. But, we are going to go over the top-rated nootropic supplement on their website — Qualia Mind. This supplement is a premium nootropic made for mental performance.  

This supplement was created from the results of thousands of hours of research and development and carries a total of 28 ingredients that are known to help enhance focus, memory, and mental clarity. 

Qualia Mind helps fix present issues while supporting your brain health in the long run. This product was designed to fuel your focus and concentration in order for you to amplify your own drive and productivity. Qualia Mind is one of the supplements that NeuroHacker offers that helps with the brain’s overall performance. 


  • Variety of supplements offered through their website 
  • Non-GMO and gluten-free
  • 100% vegan
  • Clinically researched ingredients
  • A favorite among healthcare practitioners
  • 100-day money-back guarantee 
  • Designed to help improve brain function


  • Contains chemicals that should not be taken by people on MAO inhibitors or any other psychiatric medicines
  • Not suitable for those with high blood pressure, heart conditions, cancer, or people on immunosuppressive therapy
  • Should not be taken by pregnant or nursing mothers
  • Only suitable for adults over 18 years of age


High-Quality Ingredients

Qualia Mind is made of 28 high-quality ingredients, which are designed to support and maximize cognitive functions. Qualia Mind is capable of giving your brain the nutrients it needs to perform at its best.

Huperzine A: Huperzine A has the ability to support learning, memory, executive functions, and much more. 

Celastrus Paniculatus Seed Extract: Celastrus Paniculatus is an herb that has been shown to enhance cognitive functioning by supporting memory and learning. 

Phosphatidylserine: Phosphatidylserine is an aminophospholipid found in high concentrations in the brain. Studies suggest its ability to support mental processing speed and accuracy. 

Theobromine: Theobromine is a methylxanthine related to caffeine extracted from theobroma cacao beans. Studies show how Theobromine can help support alertness and attention. 

Uridine Monophosphate: Uridine is a nucleic acid that plays a key role in different neuroregulatory processes, and it is said to support short and long-term memory. 

Organic Coffeeberry Whole Fruit Extract: Organic coffeeberry is a superfruit that contains high levels of fiber, protein, and polyphenols compared to other superfruits. These extracts are derived from farms that are certified by the Rainforest Alliance.

Ginkgo Biloba Leaf Extract: Ginkgo Biloba is a plant that contains neuroprotective and nootropic effects. Extract from the Ginkgo Biloba plant can promote a healthy aging process while supporting memory.

Rhodiola Rosea Root:  Rhodiola Rosea is a flowering plant that contains nootropic and adaptogenic effects. Its active compounds can help support memory and focus.

Taurine: Taurine is an organic amino sulfonic acid that has nootropic and neuroprotective capabilities.

Cognizin: Cognizin is a clinically tested nootropic ingredient that is designed to supply your brain with energy.

Bacopa Monnieri Leaf Extract: Research shows that Bacopa Monnieri promotes memory formation and recall.

The other ingredients listed in their formulation for Qualia Mind include Alpha-GPC, DL-Phenylalanine, Acetyl-Carnitine, L-Theanine, N-Acetyl-L-Tyrosine, Mucuna Pruriens Seed, Coleus Forskohlii Root, Artichoke Stem, and Leaf Extract, Vitamin B5, Vitamin B12, Pyrroloquinoline Quinone, Niacin, Vitamin D3, Vitamin C, Vitamin B1, Vitamin B6, and Docosahexenoic Acid. Each of these ingredients were put through trials to ensure its efficiency.

Side Effects

NeuroHacker takes into great consideration any side effects you may experience with the ingredients listed in their formula. Their ingredients are chosen with proper dosages that are unlikely to negatively affect most people who use them. This supplement is far from being a placebo. 

The ingredients in these supplements have real effects, and there are a lot of ingredients in here as well. A small percentage of people have reported experiencing muscle tightness or soreness when using these supplements, which are usually experienced in the neck, shoulders, or jaw. 

Some of the people that have experienced these symptoms have also experienced some sense of pressure in the head. The most common reason for these side effects is likely due to a choline sensitivity. 

If your side effects are intense, they recommend you stop using it immediately. If the side effects are mild and you want to explore this nootropic supplement further, you can get off of it for a few days to normalize your body. Once you do so, you can start with a low dosage to slowly build up your tolerance. 


The standard dose for most people when using Qualia Mind is seven capsules. It is preferred to take Qualia Mind first thing in the morning on an empty stomach. If you feel an upset stomach occurring, then you should take it with breakfast. 

The dosage does vary based on body weight and sensitivity, and it is not recommended to take more than 10 capsules at once or more than 12 in a day. Everyone’s body chemistry is different, so the dosage may differ from person to person. NeuroHacker encourages you to experiment with your dosage amount. 

This supplement is also designed to be taken five days on and two days off each week. By doing so, it will prevent desensitization. It does not matter if the off-cycle days are consecutive or apart, just as long as they happen each week.

Money-Back Guarantee

The refund policy NeuroHacker offers is very simple. If you’re not 100% satisfied within 100 days, you will receive 100% of your refund. They are aware it is fundamentally impossible to make a formula that will work perfectly for everybody. 

⇒ Visit the Official Website of Qualia Mind

How We Created This List – Best Nootropics

In order to put this top three list together for you, we went over the long list of nootropics that are currently out there in the industry. There are several nootropic supplements that claim to improve your brain’s functionality; however, a lot of them are filled with artificial ingredients that will not do anything for you. 

Each brand was researched deeply by looking into customer reviews and any third-party lab test reports that can ensure the efficiency of their supplements. After looking through the hundreds of nootropic supplements currently out there, we created a lengthy list of the most popular nootropic supplements in the industry. 

We dug a little deeper and began making cuts in our list to narrow down the top three best nootropic choices. We took into deep consideration why the top three below should even be considered the best of 2021. After reading our article, we are sure that you too will agree that these top three choices are the best options for this year.

What We Looked For: 

When cutting down our extensive list of nootropic supplements, we looked at each brand and its products for:

  • How effective each brand was at improving the brain’s overall functionality. This includes memory, creativity, and much more.
  • If any of the following brands listed have any side effects. If they do, we look into how severe these side effects are.
  • The brand’s overall popularity and reputation. Usually, these brands are trusted more than others.  
  • Whether or not the brands listed provide instructions on how to take their supplements.
  • If the brands listed offered any kind of money-back guarantee in case the supplements are not what the client desired.
  • Whether or not the brands listed put their supplements through clinical studies and trials before putting them on the market.
  • If the brands listed have high-quality ingredients in their supplements.
  • If the brands listed went over in detail the how’s and why’s of their product. By doing this, the brand helps the consumer understand how their product works and what it could do for them. 
  • Where the brands manufacture and produce their supplements.


By looking into all of these factors, we were able to create this shortlist for you. We looked extensively into the above mentioned criteria, ensuring our top three choices for nootropics are up to par.

Best Nootropics Brain Supplements – Buying Guide

There are so many nootropic supplements on the market claiming to do a variety of different things. It can be challenging looking through all of the loads of information out there to find the perfect one suited for your lifestyle. 

When you set out to purchase a nootropic supplement, it is important to remember that each brand creates their supplement in their own special way. 

You want to feel confident in the information you retrieve before jumping the gun and making a random choice. Although trying a new supplement is all about trial and error, you do not want to make a random choice either. 

After you have made the choice to add a nootropic supplement into your routine, it is important to remember:

Side Effects Each Nootropic Supplement May Have

It is important to know the side effects for a variety of different reasons. You want to make sure that taking any current medication will not interfere with the nootropic supplements added into your routine.  

Everyone is different, meaning that some may experience side effects while others will not. Always pay attention to your body’s reactions when you are taking a new supplement. If you notice anything severe, discontinue the use immediately and contact your doctor for further instructions.

Research Done on Each Nootropic Supplement

When narrowing down your choices on which nootropic supplement to purchase, it is best to buy those with clinical trials and studies to back up their claims.

Ingredients Used to Create Their Formulas

You always want to consider what ingredients are being used to create the supplements. Some brands carry artificial ingredients and fillers in their formulas that are not healthy for you to consume consistently. 

It is always a good decision to go for a formulation that carries high-quality ingredients that were also put through clinical trials and studies to show its safety and effectiveness.

After taking these topics into consideration when making your purchase, we are confident you will be able to narrow down your choices in finding the best one suited for you. 

We are optimistic that this list that we put together for you is a great place for you to start when diving into the world of nootropic supplements.

FAQs: Nootropics

Q1. Are Nootropics Safe to Use?

As long as you are using a brand that has little to no side effects, the nootropic supplement itself should be safe for usage. In order to ensure it is safe, make sure you are using the correct dosage, and pay attention to your body’s reactions as well.

Q2. Can Anyone Use Nootropics?

The answer to that is no, not everyone can use nootropic supplements. Make sure to always check the label before you take any of the following supplements to make sure you are eligible to take them. Usually, anyone under the age of 18, pregnant women, nursing women, and people with certain ailments cannot use nootropic supplements.

Q3. Can I Mix My Nootropic Supplements with Other Medications I Am Taking? 

If you are currently taking any medications that may interfere with the nootropic supplements, you should consult your doctor before starting the usage.

Q4. Can Any Other Stimulants Be Taken with Nootropic Supplements? 

When starting a nootropic supplement, it is best to avoid mixing it with other stimulants. This reason is that the two stimulants being mixed may cause a reaction. It is better to start with one stimulant first to allow your body to adjust to it before adding anything drastic like another stimulant.


We have gathered research on all of the popular nootropics in the industry and have narrowed it down to the top three brain-stimulating supplements. 

We are sure these top three nootropic supplements will be able to help you increase your brain’s overall functionality. So, choose one from our list today to start enhancing your mental capacity.

Best Nootropics Supplements & Smart Drugs of 2022

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